SIGATECH DP 100/10 mg Tablet is a combination oral antidiabetic medication containing:

• Dapagliflozin 10 mg: A Sodium-Glucose Co-Transporter 2 (SGLT2) inhibitor that lowers blood glucose by promoting urinary glucose excretion.

• Sitagliptin 100 mg: A Dipeptidyl Peptidase-4 (DPP-4) inhibitor that increases incretin hormones to enhance insulin secretion and suppress glucagon.

This dual-action tablet is used for improving glycemic control in patients with Type 2 Diabetes Mellitus (T2DM).

USES

• Management of Type 2 Diabetes Mellitus in adults

• As adjunct to diet and exercise to improve blood sugar levels

• Suitable for patients who need combination therapy to achieve better glycemic control

• May be used alone or with other antidiabetic agents

BENEFITS

• Dual mechanism: reduces blood sugar by increasing glucose excretion and enhancing insulin secretion

• Low risk of hypoglycemia when used alone or with non-secretagogue agents

• Weight loss or weight-neutral effect

• May provide cardiovascular and renal benefits (particularly via dapagliflozin)

• Convenient once-daily dosing to improve compliance

SIDE EFFECTS

Common Side Effects:

• Increased urination

• Genital yeast infections

• Urinary tract infections

• Nasopharyngitis (common cold symptoms)

• Headache

• Gastrointestinal discomfort (nausea, diarrhea)

Serious Side Effects:

• Diabetic ketoacidosis (rare but serious)

• Hypersensitivity reactions

• Dehydration or low blood pressure

• Pancreatitis (rare, associated with Sitagliptin)

• Lactic acidosis (rare, if combined with other agents like metformin)